Mersin University which was established with Law No. 3837 that was accepted by Parliament on July 3, 1992, became active on November 10, 1992. The university which reached the age of fourteen in the academic year of 2005-2006, gave its first graduates in June of 1997. The university which started education in the academic year of 1993-1994 as taking students to Faculty of Arts and Sciences, Faculty of Fine Arts, Faculty of Economics and Administrative Sciences, Faculty of Engineering, School of Tourism and Hotel Management, Gulnar Vocational School, Mut Vocational School, Tarsus Vocational School, and to the Institutes of Social Sciences and of Natural and Applied Sciences that will conduct the programmed of graduate school.
Faculty of Fisheries in the academic year of 1995-1996 and Faculty of Medicine in the academic year of 1998-1999 became active. Medical School Research and Training Hospital was opened on March 15, 1999.
Mersin University increased the number of faculties to 11 by adding Faculties of Education and Faculties of Architecture in 1999; Faculty of Pharmacy in 2000; Tarsus Faculty of Technical Education and Communication in 2001 to its 6 faculties of present.
State Conservatoire was opened by taking students at the secondary education level in the academic year of 1994-1995; it began the undergraduate program in the academic year of 1997-1998. School of Health in the academic year of 1998-1999, School of Physical Education and Sports in the academic year of 1999-2000, and School of Jewelry Design and Technology in the academic year of 2002-2003 started teaching. President's Office Department of Foreign Languages was converted into a School of Foreign Languages in the academic year of 2003-2004, Erdemli School of Applied Technology and Business on June 27, 2005, Tarsus School of Applied Technology and Business on December 9, 2005, and with the establishment of Silifke School of Applied Technology and Business on September 30, 2006, the number of colleges increased to 9. While there are four Vocational Schools in the establishment, there are eleven Vocational Schools today at the university. These are Vocational Schools of Anamur, Aydincik, Erdemli, Gulnar, Mut, Silifke, Tarsus, Mersin, Medical Services, Social Sciences and Technical Sciences.
Alongside with Institutes of Social Sciences and Institutes of Natural and Applied Sciences, Graduate School of Health Sciences started education at graduate and doctoral level by going into operation in spring semester of academic year of 1999-2000. The number of research center in the university has increased to fourteen by opening Advanced Technology Education Research and Application Center finally.